Original articlePredictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study☆
Section snippets
Materials and methods
The AGIS design and methods are described in detail elsewhere and are summarized here.2, 23 Thirty-five- to 80-year-old phakic patients with open-angle glaucoma no longer controlled by maximally tolerated medical treatment were recruited. Eligible eyes had a best-corrected visual acuity (VA) score of at least 56 letters (Early Treatment Diabetic Retinopathy Study) and met specified criteria for combinations of consistently elevated intraocular pressure (IOP), glaucomatous VF defect, and optic
Results
A total of 151 eyes (29.9%) progressed according to the PLR criteria, whereas 138 eyes (27.1%) showed progression based on AGIS criteria (κ = 0.30, percentage agreement = 64%). The characteristics of the study sample are presented in Table 2 based on occurrence of progression according to PLR criteria. Four eyes were considered indeterminate based on our PLR criteria and were excluded from further analysis. Table 3 describes the results of the multivariate logistic regression. Four variables
Discussion
The baseline characteristics of our subgroup of AGIS patients are similar to those of the original cohort of patients described in previous AGIS reports.2 In this investigation, we used rigorous and clinically relevant PLR criteria to define the main outcome measure, VF worsening. We detected VF progression in approximately 30% of the eyes, which is consistent with the number of eyes showing progression in the same cohort according to the AGIS criteria (27%). We found that greater intervisit
Acknowledgements
The authors thank all the AGIS investigators for their contributions.
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Manuscript no. 240023.
Supported by an unrestricted grant from Research to Prevent Blindness, New York, New York, and the National Institutes of Health, Bethesda, Maryland (grant no.: R01 EY12738).
The authors do not have any commercial or proprietary interest in any of the products or companies cited in the article. Likewise, they have no financial interest in and have not received payment as a consultant, reviewer, or evaluator from any of the companies mentioned.