Original articleCentral corneal pachymetry and visual field progression in patients with open-angle glaucoma☆
Section snippets
Patients and methods
The Human Subjects Division of the University of Washington approved this retrospective study. All patients were selected from a database of patients seen between April and November 2000, which served as the basis of a previous report.21 All patients who met the following inclusion criteria were enrolled in this study: (1) at least 2 years of follow-up with Humphrey visual fields; (2) the patient demonstrated visual field progression with criteria modified from Anderson and described below; (3)
Results
Forty-four eyes of 44 patients met inclusion criteria and were matched with 44 eyes of 44 control subjects. Demographic data and initial characteristics are listed in Table 1. The diagnosis of glaucoma was made in 3 patients between 1975 and 1980, in 4 patients between 1981 to 1985, in 14 patients between 1986 and 1990, and in 24 patients after 1990. There was no significant difference between the subjects and the matched control group in age at diagnosis, age at pachymetry, follow-up time,
Discussion
In our study of the association of CCT and visual field progression in patients with OAG, we found that those eyes with progression had a thinner mean CCT than those who did not progress (529 vs. 547 μm; P = 0.02) (Table 1). Thinner CCT was significantly associated with progression in the multivariate analysis also (Cox regression, P = 0.02). We found a HR of 1.44 per 40 μm thinner CCT (95% CI, 1.12–1.80).
To place this figure in perspective, for a 40-μm decrease in CCT, the OHTS found a
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2020, OphthalmologyCitation Excerpt :We found no evidence for CCT as a risk factor for visual field deterioration in the UKGTS in the univariate analysis (HR, 1.00; 95% CI, 0.99–1.00; P = 0.34). Central corneal thickness has been referred to as an independent risk factor for the conversion of ocular hypertension to glaucoma49 and glaucoma progression.8,50 However, CCT is a known confounder of IOP measurement by GAT,51,52 and the interaction of CCT with the corneal biomechanical properties53 means that IOP measurements cannot be corrected for CCT without knowing the corneal material properties.
Primary Open-Angle Glaucoma
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2016, OphthalmologyCorrelation between central corneal thickness and myopia in Taiwan
2014, Kaohsiung Journal of Medical SciencesAn evidence-based review of prognostic factors for glaucomatous visual field progression
2013, OphthalmologyCitation Excerpt :We noticed a considerable amount of heterogeneity in 3 probable prognostic factors for OAG: baseline visual field loss, baseline IOP, and CCT. Although more baseline visual field loss was associated with more progression in most studies, 6 of 36 studies showed that a better baseline visual field was associated with more progression in the multivariable analysis.19–24 However, only 1 study, part of the Advanced Glaucoma Intervention Study, found a statistically significant result.24
Glaucoma risk assessment using a non-linear multivariable regression method
2012, Computer Methods and Programs in BiomedicineCitation Excerpt :More specifically, CCT has been implicated as a risk factor for the development of primary open-angle glaucoma (POAG) and the progression of glaucomatous visual field defects among ocular hypertensive patients [2,3] and patients with preperimetric glaucomatous optic neuropathy [4]. However, it has been reported that clinically detectable glaucomatous structural alteration of the ONH (optic nerve head) may precede the development of reproducible white on white [5–9] and blue on yellow [8–10] visual field (VF) defects by up to several years. Correspondingly, CCT was the most consistent predictor of the degree of glaucomatous optic nerve head structural damage [11].
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Manuscript no. 240046.
Supported in part by an unrestricted departmental grant from Research to Prevent Blindness, Inc., New York, New York.
The authors have no financial or proprietary interest in any product mentioned within this article.