Original articleIntermittent and Chronic Ultraviolet Light Exposure and Uveal Melanoma: A Meta-analysis
Section snippets
Materials and Methods
The detailed methods of this study have been described.1 To summarize, 3 researchers (CPS, EW, ML) independently searched the literature using Medline (with both Ovid and PubMed), EMBASE, MD Consult, and the Web of Science using the following keywords: ultraviolet, ultraviolet, sun, sunlight, uveal melanoma, eye cancer, eye melanoma, uveal melanoma, nevus, and risk factor. The authors critically evaluated each study and included original observation studies that examined ultraviolet light risk
Results
After a search of the literature, 133 studies were identified that provided data on either host factors or ultraviolet light exposure. Of the 18 caseācontrol studies and 2 cohort studies15, 26 that satisfied all inclusion criteria, 12 studies provided data on ultraviolet light exposure and uveal melanomaā (Fig 1) (Table 2, Table 3, Table 4). The remaining 8 studies assessed other variables, such as eye color or nevi.
Discussion
Several epidemiological studies have examined the relationship between ultraviolet light exposure and the risk of uveal melanoma, but these studies report varying results.ā Even after aggregating studies to calculate summary statistics, this meta-analysis yielded inconsistent evidence associating ultraviolet light with the development of uveal melanoma. There was evidence for welding as a risk factor, but not for outdoor leisure, occupational sunlight exposure, or birth latitude.
It is
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2022, Canadian Journal of OphthalmologyCitation Excerpt :Despite continuous advances in the treatment of uveal melanoma reducing enucleation rates, no tangible improvements in survival have been achieved over the past 4 decades,3 highlighting the importance of identifying modifiable risk factors. Prior meta-analyses have evaluated the association between UV radiation and uveal melanoma,9,10,12 and concluded that arc welding, but no other form of UV radiation, is a statistically significant risk factor (see Table 3). Unfortunately, the small number of studies available for analysis at the time of these prior meta-analyses did not allow for sunlamp use to be analyzed.
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Manuscript no. 2005-60.
Dr Lajous is funded by the National Council of Science and Technology, Mexico City, Mexico.
There are no conflicts of interest.