Original ArticleLong-term Results of Submacular Surgery Combined with Macular Translocation of the Retinal Pigment Epithelium in Neovascular Age-Related Macular Degeneration
Section snippets
Materials and Methods
Of the 9 original trial patients, 3 could not be contacted (one of whom had moved abroad), and 1 was known to be deceased. Two of the 6 contacted declined further investigation: one because she was terminally ill with cancer and the other because he was immobile as a result of a cerebrovascular accident. The 4 remaining patients agreed to return to the eye hospital for review and repeat investigations. These corresponded to male patients 2, 3, 4, and 6 from the original study and are
Results
All 4 patients offered positive comments about having been in the original trial, and none had suffered a recurrence of CNVs in either eye during the 5 to 6 years of follow-up. Two patients (3 and 6) felt their vision had improved as a result of surgery, patient 2 felt no change, and patient 4 felt his vision had declined further. Patient 4 also had underlying unilateral glaucoma, which had advanced significantly over the subsequent 5 years after surgery, and his left optic disc showed
Discussion
The 5- to 6-year follow-up of 4 of 9 AMD patients who originally underwent removal of CNVs with translocation of extrafoveal RPE across the macula revealed a further decline in VA and loss of foveal fixation. The decline occurred after the original description of the technique at the 2-year follow-up. Late changes in autofluorescence were also noted: increasing over the graft donor site and virtually disappearing over the graft itself.
Although the long-term results of this pilot study are
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Manuscript no. 2005-313.
Supported by the June Sutor Research Fellowship, London, United Kingdom; Frances Renée Hock Fund, London, United Kingdom; and Moorfields Trustees, London, United Kingdom.
The authors have no proprietary or financial interest related to the article or any technique described herein.