Original ArticleCorrelation between Optical Coherence Tomography and Fluorescein Angiography Findings in Diabetic Macular Edema
Section snippets
Patients and Methods
Four eyes of 4 patients with diabetes and DME (4 men) ages 58 (patient 1), 56 (patient 2), 39 (patient 3), and 57 years (patient 4) were included. In addition to a routine ophthalmic examination, FA and Stratus OCT were performed in all eyes.
We compared the late-phase angiograms (10–12 minutes after injection) with the corresponding cross-sectional OCT images. All eyes were examined using 5.0-mm scan lengths that included the fovea (1.8 mm in diameter) and the adjacent perifoveal region (1.6 mm
Results
The late-phase fluorescein angiograms of the foveal area showed a petalloid pattern of hyperfluorescence in all eyes, of which 3 (patients 1, 2, and 3) had cystic spaces mainly in the OPL on OCT. The remaining eye (patient 4) had no cystic spaces but retinal swelling in the OPL on OCT. In 16 perifoveal areas in 4 eyes, FA showed a honeycomb pattern of hyperfluorescence in 7 areas (patients 2 and 3), petalloid pattern in 3 areas (patient 4), and diffuse pattern in 3 areas (patients 1 and 2). The
Discussion
Our comparative study using FA and OCT for DME revealed that dye pooling with a petalloid pattern in the foveal area corresponded to cystic spaces in the OPL, and a honeycomb pattern corresponded to cystic spaces in the INL in the perifoveal area. In this series, FA findings did not always correspond to those of OCT. In the foveal area, 3 of 4 eyes with a petalloid pattern of hyperfluorescence had cystic spaces in the OPL, whereas 1 eye (patient 4) had no cystic spaces but retinal swelling.
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Manuscript no. 2005-1138.