Original ArticleCytomegalovirus as a Cause of Anterior Uveitis in Immunocompetent Patients
Section snippets
Patients and Methods
We included 7 patients with a chronic and/or recurrent unilateral anterior uveitis, persisting despite local steroid therapy, who had a positive anterior chamber fluid analysis for CMV. Chronic uveitis was defined as active intraocular inflammation for at least 3 months. Persistent unilateral anterior uveitis, sometimes complicated by severe increases in IOP, was the indication for an anterior chamber tap to determine whether an infectious cause could be identified. Anterior chamber
Results
The clinical features of our patients are summarized in Table 1, Table 2. Three patients (1, 4, and 5) are described in more detail.
We included 1 female and 6 male patients with unilateral chronic and/or recurrent anterior uveitis. The fellow eye did not have any abnormalities. The mean age of onset of uveitis was 43 years (range, 11–61 years). Patients were all healthy except for their uveitis. More specifically, laboratory workup and screening by an internist did not reveal any immunologic
Discussion
This series describes a somewhat variable clinical picture in 7 immunocompetent patients with CMV anterior uveitis. All patients were suffering from a mild, isolated, unilateral, chronic, and/or recurrent anterior uveitis. Corneal findings included diffuse keratic precipitates and focal corneal haze/edema (endotheliitis), sometimes related to surgical incision sites. On activation of the uveitis, IOP increases were noted in all patients, occasionally reaching values of 50 to 70 mmHg. Topical
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2021, Photodiagnosis and Photodynamic TherapyCitation Excerpt :However, recent reports have shown that CMV infection is a cause of hypertensive anterior uveitis and corneal endotheliitis that presents as acute or chronic inflammation in the immunocompetent individual. In immunocompetent patients, ocular manifestations are limited to the anterior segment [5–8]. CMV anterior uveitis accounts for as high as 22.8%–28.6% of cases of anterior uveitis associated with raised intraocular pressure (IOP). [2,5]
Manuscript no. 2006-444.