Original articlePrevalence of Primary Open-angle Glaucoma in an Urban South Indian Population and Comparison with a Rural Population: The Chennai Glaucoma Study
Section snippets
Study Design and Population
The details of the study design and sampling plan were published elsewhere.1 In brief, the Chennai Glaucoma Study was designed to estimate the prevalence of glaucoma. A sample size of 4758 was arrived at assuming an 85% response rate for an assumed 3% population prevalence of glaucoma with a relative precision of 25% and a design effect of 2. Therefore, 4800 subjects each from the rural and urban populations were enumerated. Sample selection for the urban component of the study was done using a
Results
A total of 3850 subjects of the enumerated 4800 participated in the study (response rate, 80.2%). One thousand seven hundred ten (44.4%) were male, and 2140 (55.6%) were female. The mean age of the study population was 54.8±10.6 years (range, 40–103). Of 950 nonparticipants (19.8%), 577 were male (60.7%) and 373 (39.3%) were female. There were 2532 subjects with normal and reliable suprathreshold VF testing using frequency-doubling perimetry in both eyes. Using the right eye of these subjects,
Discussion
The main purpose of the Chennai Glaucoma Study was to estimate the prevalence of glaucoma in rural and urban populations in southern India. Interesting findings in the present study are a higher prevalence of POAG in the urban population and differences between the rural and urban populations in various parameters. The age- and gender-adjusted prevalence of POAG in the urban population was 3.47% (95% CI, 2.9%–4.1%). There was a significant increase in prevalence of POAG with age, and there was
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2022, Progress in Retinal and Eye ResearchCitation Excerpt :For example, when diagnostic criteria from different large epidemiological studies were applied to one analytical dataset, prevalence estimates varied by up to 10-fold (Wolfs et al., 2000). To address this issue, the International Society for Geographical and Epidemiological Ophthalmology (ISGEO) published a consensus definition of POAG for epidemiological studies (Foster et al., 2002), and a growing number of studies now report according to this classification (Casson et al., 2007; He et al., 2006; Iwase et al., 2004; Jonasson et al., 2003; Rahman et al., 2004; Raychaudhuri et al., 2005; Shen et al., 2008; Sia et al., 2010; Vijaya et al., 2005, 2008; Wang et al., 2010). However, even comparisons between ISEGO-compliant studies are not straight-forward due to lack of standardisation of prevalence, particularly for age.
Manuscript no. 2006-1273.
Financial support: Chennai Willingdon Corporate Foundation, Chennai, India.
No conflicting interests.