Original articleGlaucoma Is Associated with Peripheral Vascular Endothelial Dysfunction
Section snippets
Participants
Patients with NTG (n = 30), POAG (n = 30), and age- and gender-matched normal controls (n = 30) were recruited for this study. The NTG and POAG patients were recruited from the glaucoma clinic of Chang Gung Memorial Hospital. The normal controls were recruited from patients undergoing routine medical examinations in the same hospital. The diagnostic criteria for NTG were as follows: untreated IOP not exceeding 22 mmHg measured at varying intervals from 8 am to 5 pm, open anterior chamber angles
Results
Table 2 lists the demographics for the NTG, POAG, and control groups. Table 3 lists the vascular parameters in the 3 groups. The FMD values were 2.70±2.25% in the NTG group, 5.33±2.81% in the POAG group, and 7.21±2.36% in the control group (P<0.001). Multiple comparisons between groups also differed significantly. Meanwhile, the NMD values were 12.95±5.82% in the NTG group, 15.62±4.29% in the POAG group, and 16.01±5.00% in the control group (P = 0.044). However, no significant difference was
Discussion
Several studies have shown impaired vascular endothelial function in patients with NTG,12, 13, 14 but data for POAG patients have not been reported. The analytic results of this study indicated that FMD in patients with NTG, in those with PAOG, and controls significantly differed. The NTG group tended to exhibit severe vascular endothelial dysfunction, and the POAG group demonstrated moderate impairment. Although IOP currently is considered the most important risk factor for developing
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Manuscript no. 2007-688.