Original articleConservative Treatments of Intraocular Retinoblastoma
Section snippets
Patients and Methods
This was a single-center study designed as a phase II, prospective, nonrandomized evaluation of a conservative treatment strategy for the management of retinoblastoma.
This therapeutic approach comprises the use of different treatment modalities such as chemothermotherapy, thermotherapy, cryoapplication, and plaque brachytherapy, preceded by neoadjuvant chemotherapy when the tumor volume at diagnosis is important.
The primary objective was to allow conservative management of the eye by decreasing
Results
From December 1998 to March 2002, 83 children were included in this study. During this same period, 195 children were treated for retinoblastoma in our institute. Thirty-eight children were not included for the following reasons: follow-up could not be ensured (14); already treated elsewhere (17, 15 of whom were also likely to present a problem of follow-up); concomitant disease (homozygous sickle-cell anemia, suprasellar primitive neuroectodermal tumor, severe hematologic and hepatic
Discussion
This study reports the results in terms of tumor control of a therapeutic strategy comprising a phase of chemoreduction for a majority of children (2 cycles of a combination of etoposide and carboplatin), followed by local therapies or chemothermotherapy. The results are very positive, confirming the efficacy of this strategy for tumor control, with the exception of initially very advanced forms. Tumor control was obtained in the great majority of cases (84%), with the need for EBR in only 9
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Manuscript no. 2007-687.
The study received a grant from the Programme Hospitalier de Recherche Clinique and funding from the Association pour la Recherche sur le Cancer, Villejuif, France, and Retinostop, Paris, France, for the purchase of the Retcam equipment.