Original articleLow Luminance Visual Dysfunction as a Predictor of Subsequent Visual Acuity Loss from Geographic Atrophy in Age-Related Macular Degeneration
Section snippets
Patients and Methods
A National Institutes of Health-funded prospective natural history study of GA resulting from AMD was conducted at the Wilmer Eye Institute between 1992 and 2000. The study was approved by the Johns Hopkins University School of Medicine's Institutional Review Board, and written informed consent was obtained from all study participants. This study adhered to the Declaration of Helsinki. One hundred fifty-eight subjects enrolled. The primary entry criterion was having GA as a result of AMD,
Results
Table 1 gives the baseline characteristics for the 91 participants with 2-year data.
Low Luminance Visual Dysfunction
These prospective natural history data show that the LLD, a simple, inexpensive, and rapid measure of visual function, was a strong predictor of the subsequent risk for losing VA in eyes with GA. This measure was studied because of the clear difficulties experienced by participants with GA in dim illumination and the body of research showing reductions in dark-adapted function in patients with AMD. The authors previously showed, in a small pilot study, that in eyes with drusen with reduced
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Manuscript no. 2007-977.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Institutes of Health, Bethesda, Maryland (grant nos.: EY08552 and EY14148).