Original articleβ-Zone Parapapillary Atrophy and the Velocity of Glaucoma Progression
Section snippets
Patients and Methods
The New York Glaucoma Progression Study (GAPS) consisted of 43 660 consecutive subjects (132 512 VF tests) evaluated in the glaucoma referral practice of the authors (JML, RR, CT) from January 1999 through December 2008. After an initial visit consisting of a complete ophthalmologic examination, perimetry (24-2 Swedish interactive threshold algorithm [SITA] standard automated perimetry, Humphrey Field Analyzer II; Carl Zeiss Meditec, Inc., Dublin, CA) and optic disc stereophotographs, patients
Results
Two hundred forty-five eyes (245 patients) met the entry criteria. The mean age ± standard deviation was 69.6±12.3 years; 62% were women and 84% were of European descent. All subjects were treated with a variety of glaucoma treatments. Mean follow-up was 4.9±1.4 years, and the mean number of VFs was 9.3±2.7. Baseline characteristics of the 2 groups are shown in Table 1.
β-Zone PPA was present in 146 eyes (65%; group A). The average β-zone PPA size was 0.93±0.74 mm2. In the univariate analysis,
Discussion
The presence of β-zone PPA as a risk factor for global rates of VF progression was evaluated using automated pointwise linear regression. Patients with β-zone PPA based on stereophotography, measured by HRT-II, and an adequate number of VFs after the HRT image were evaluated for progression. Glaucomatous eyes with β-zone PPA progressed faster than eyes without β-zone PPA, and the presence of any amount of β-zone PPA increased the risk of progression.
The association between PPA and glaucoma was
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2021, Ophthalmology GlaucomaCitation Excerpt :This study also found that the maximum radial width of β-zone PPA was larger in NTG than in contralateral healthy eyes, as well as being associated with an increased risk of NTG. β-zone PPA is more frequent in patients with GON than in healthy people and increases the risk for glaucoma progression.25,53–55 Moreover, the maximum radial width of β-zone PPA was shown to correlate spatially with the location of RNFL defects56 and with the location of the most rapid future visual field progression in glaucomatous eyes.57
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Manuscript no. 2009-595.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the Catherine and Ephraim Gildor Research Fund of the New York Glaucoma Research Institute, New York, New York.