Original articleEvaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Prospective Analysis with Neuroretinal Rim and Visual Field Progression
Section snippets
Patients
One hundred eight eyes from 70 glaucoma patients followed up from November 2005 through March 2010 were included. At the baseline examination, all subjects underwent a full ophthalmic examination, including visual acuity, refraction, intraocular pressure measurement with Goldmann tonometry, gonioscopy, and fundus examination. The inclusion criteria were best-corrected visual acuity of not worse than 20/40 and spherical refractive error between −10.0 and +6.0 diopters (D) with less than 5.0 D of
Results
One hundred eight eyes from 70 glaucoma patients were followed up prospectively every 4 months for at least 2.9 years (median, 3.2 years; range, 2.9–3.9 years) with RNFL, neuroretinal rim, and visual field measured at each visit. There were a total of 1105 observations for OCT, 1062 for HRT III, and 1099 for visual field, with an average of 10.2±0.8, 9.8±1.0, and 10.2±0.8 observations available for each eye for analyses. At baseline, 27.7% (30 eyes) had advanced glaucoma (MD<–12 dB), 29.6% (32
Discussion
To the best of the authors' knowledge, this is the first study prospectively comparing the performance of progression detection and the rate of RNFL, neuroretinal rim, and visual field progression in patients with glaucoma. In contrast to a retrospective design in which the follow-up duration, frequency, and number of investigations may vary considerably among patients, all subjects analyzed in this prospective study were followed up every 4 months, with investigations performed using a
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Impact of Glaucoma Severity on Rates of Neuroretinal Rim, Retinal Nerve Fiber Layer, and Macular Ganglion Cell Layer Thickness Change
2022, American Journal of OphthalmologyCitation Excerpt :The MRW, RNFL, and GCL thickness have been reported to have different dynamic ranges, with each parameter reaching the measurement floor at different time points through the disease.15,30 These parameters are known to have different progression patterns and temporal relationships across the spectrum of glaucoma damage;31-33 however, the current study suggests a relatively constant rate of change in these parameters. The LME model 1 showed that the rate of change was not significantly influenced by baseline MD.
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2020, Progress in Retinal and Eye ResearchCitation Excerpt :Broadly, optic disc area ranges from 2 to 3 mm2, and the normal NRR area is approximately 1.5 mm2 (Abe et al., 2009; Bourne et al., 2008; Healey et al., 1997; Wang et al., 2006; Xu et al., 2007). Linearly measured cup-to-disc ratio is about 0.3–0.5, and usually increases significantly with increasing disc area (Leung et al., 2011; Zangwill et al., 2013). In glaucoma, as rim area decreases, the cup-to-disc ratio can increase up to nearly 1.0 in far advanced cases.
Manuscript no. 2010-655.
Financial Disclosure(s): The author(s) have made the following disclosure(s): Christopher Kai Shun Leung - Financial support - Carl Zeiss MeditecRobert Neal Weinreb - Consultant and Financial support - Carl Zeiss Meditec