Original articleVitrectomy with Internal Limiting Membrane Peeling versus No Peeling for Idiopathic Full-Thickness Macular Hole
Section snippets
Methods
We undertook a systematic review and meta-analysis using individual participant data (IPD) under the auspices of the Cochrane Eyes and Vision Group.12
Search Results
The search strategy resulted in 172 titles and abstracts (Fig 1). Four RCTs were identified16, 17, 18, 19, 20; IPD were received from 3 RCTs.16, 17, 18 One RCT had been published only in an abstract form (ARVO Meeting Abstracts 2009;50:5206), and no IPD were available at the time this systematic review and IPD meta-analysis were undertaken. Data from this published abstract could be used for 1 outcome (macular hole closure). The number of patients (eyes) included in the IPD meta-analysis were
Discussion
This was a successful IPD collaboration that enabled the inclusion of results from 3 of the 4 identified randomized trials. This allowed more precise results than for a single study alone, and we have increased the generalizability of the results by including a range of international studies. We also were able to use the IPD to adjust our results for important covariates. We hope to update the review with results from the fourth trial once these data have been published.
Four RCTs16, 17, 18
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The Effect of Macular Hole Duration on Surgical Outcomes: An Individual Participant Data Study of Randomized Controlled Trials
2023, OphthalmologyCitation Excerpt :We attempted to contact all corresponding authors via email and requires IPD from their study participants. In total, 12 studies provided IPD that represented 940 eyes.25,28,33–37,40-44 All authors who replied were willing to share data.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Funding: NHS Grampian Endowments Grant. The NHS Grampian had no role in the design and conduct of this research.