A recent paper suggests that supplementing the diet with large amounts of vitamin A may overcome some inherited blindness. But it also raises some serious questions.
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References
Bressler, N.M., Bressler, S.B. & Fine, S.L. Age-related macular degeneration. Surv. Ophthalmol. 32, 375–413 (1988).
Hamilton, W.K., Ewing, C.C., Ives, E.J. & Carruthers, J.D. Sorsby's fundus dystrophy. Ophthalmology 96, 1755–1762 (1989).
Capon, M.R.C. et al. Sorsby's fundus dystrophy. A light and electron microscopic study. Ophthalmology 96, 1769–1777 (1989).
Weber, B.H.F., Vogt, G., Wolz, W., Ives, E.J. & Ewing, C.C. Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter. Nature Genet. 7, 158–161 (1994).
Apte, S.S., Mattei, M.-G. & Olsen, B.R. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19, 88–90 (1994).
Weber, B.H.F., Vogt, G., Pruett, R.C., Stohr, H. & Felbor, U. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nature Genet. 8, 352–356 (1994).
Jacobson, S. et al. Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nature Genet. 11, 27–32 (1995).
Birkedal-Hansen, H. et al. Matrix metalloproteinases: A review. Crit. Rev. Oral Biol. Med. 4, 197–250 (1993).
Acott, T.S. The biochemistry of aqueous outflow. in Textbook of Ophthalmology (eds Podos, S., Yanoff, M., Kaufman, P.A. & Mittag, T.), 7, 1.47–1.78 (Mosby, London, 1994).
Denhardt, D.T., Feng, B., Edwards, D.R., Cocuzzi, E.T. & Malyankar, U.M. Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions. Pharmac. Ther. 59, 329–341 (1993).
Leco, K.J., Khokha, R., Pavloff, N., Hawkes, S.P. & Edwards, D.R. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J. biol. Chem. 269, 9352–9360 (1994).
Willenbrock, F. et al. The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions. A kinetic analysis of the inhibition of gelatinase A. Biochemistry 32, 4330–4337 (1993).
Williamson, R.A., Smith, B.J., Angal, S., Murphy, G. & Freedman, R.B. Structural analysis of tissue inhibitor of metalloproteinases-1 (TIMP-1) by tryptic peptide mapping. Biochim. biophys. Acta 1164, 8–16 (1993).
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Acott, T., Weleber, R. Vitamin A megatherapy for retinal abnormalities. Nat Med 1, 884–885 (1995). https://doi.org/10.1038/nm0995-884
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DOI: https://doi.org/10.1038/nm0995-884