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Angiogenesis, lymphangiogenesis, and melanoma metastasis

Oncogene volume 22, pages 3172–3179 (2003)Cite this article

Abstract

The induction of angiogenesis is a critical point in the development of most human tumors – including melanomas. Some of the earliest studies in the field of tumor angiogenesis showed that transplantation of human melanoma fragments into the hamster cheek pouch stimulated blood vessel growth. Since then, numerous studies have demonstrated that human melanomas also induce angiogenesis. The prognostic importance of the degree of melanoma vascularization, however, has remained controversial. Elevated expression of several angiogenic factors, including vascular endothelial growth factor, basic fibroblast growth factor, and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. Based upon these findings, several clinical trials of angiogenesis inhibitors have been initiated in human melanoma patients and are currently underway. Recent experimental evidence indicates that tumor-associated lymphangiogenesis also plays an important role in mediating tumor spread to regional lymph nodes. These observations have important implications for prognosis and treatment of human melanomas.

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Acknowledgements

This work was supported by NIH/NCI Grants CA69184, CA86410 and CA91861 (MD), by American Cancer Society ProgrAm. Project Grant 99-23901 (MD), and by the Cutaneous Biology Research Center through the Massachusetts General Hospital/Shiseido Co. Ltd Agreement (MD).

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  1. Berlex Biosciences, Richmond, 94804, CA, USA

    Michael Streit

  2. Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, MA, USA

    Michael Detmar

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Streit, M., Detmar, M. Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 22, 3172–3179 (2003). https://doi.org/10.1038/sj.onc.1206457

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