Abstract
Tacrolimus (FK506) has been used successfully as a systemic immunomodulator for more than 2 decades, and numerous studies have investigated its mechanisms of action. Systemic and topical tacrolimus have been investigated as treatments for ocular surface disorders that may have an immune-based inflammatory component. In these studies, tacrolimus has shown efficacy in corneal graft rejection, inflammatory conjunctival and corneal diseases, uveitis, and graft-versus-host disease. As these disorders are often refractory to other available treatments, ophthalmic or systemic tacrolimus is a welcome nontoxic adjunct or replacement to potentially toxic topical or systemic immunosuppressive therapies.
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References
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Acknowledgments
This work was supported by the Fundamental Research Funds of State Key Lab (Grant number 303060202400413).The authors have no conflicts of interest that are directly relevant to the content of this review.
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Zhai, J., Gu, J., Yuan, J. et al. Tacrolimus in the Treatment of Ocular Diseases. BioDrugs 25, 89–103 (2011). https://doi.org/10.2165/11587010-000000000-00000
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DOI: https://doi.org/10.2165/11587010-000000000-00000