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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target

Author(s): A. Klettner and J. Roider

Volume 9, Issue 9, 2009

Page: [1127 - 1135] Pages: 9

DOI: 10.2174/138955709788922665

Price: $65

Abstract

The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.

Keywords: VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap


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