Abstract
A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects from the systemic absorption of topically applied ophthalmic agents in children.
MeSH terms
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Adrenergic alpha-Agonists / administration & dosage
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Adrenergic alpha-Agonists / poisoning*
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Brimonidine Tartrate
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Coma / complications
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Coma / etiology*
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Coma / prevention & control
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Eye Abnormalities / complications
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Humans
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Infant, Newborn
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Male
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Ophthalmic Solutions / administration & dosage
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Ophthalmic Solutions / poisoning*
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Practice Guidelines as Topic
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Quinoxalines / administration & dosage
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Quinoxalines / poisoning*
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Syndrome
Substances
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Adrenergic alpha-Agonists
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Ophthalmic Solutions
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Quinoxalines
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Brimonidine Tartrate