Abstract
Thirty-four patients with early relapsing-remitting multiple sclerosis (RRMS) were studied to clarify the differences in chemokine receptor usage by blood and cerebrospinal fluid (CSF) lymphocytes relevant to the pathogenesis of MS. A total of 45 examinations (33 active and 12 inactive stages) revealed that circulating CD4+CXCR3+ T helper 1 (Th1) cells were increased in active MS patients and correlated with the number of gadolinium-enhanced lesions on magnetic resonance (MR) images. In contrast, CSF samples obtained during active stages were characterized by a decrease in the percentage of CD8+CXCR3+ T cells, which was inversely correlated with CSF cell count and intra-blood-brain barrier (BBB) IgG production.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Antigens, Surface / immunology
-
CD4 Antigens / immunology
-
CD8 Antigens / immunology
-
Central Nervous System / immunology*
-
Central Nervous System / pathology
-
Central Nervous System / physiopathology
-
Chemokines / immunology*
-
Female
-
Humans
-
Immunity / immunology*
-
Male
-
Middle Aged
-
Multiple Sclerosis, Relapsing-Remitting / blood
-
Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid
-
Multiple Sclerosis, Relapsing-Remitting / immunology*
-
Predictive Value of Tests
-
Receptors, CXCR3
-
Receptors, Chemokine / blood
-
Receptors, Chemokine / immunology*
-
T-Lymphocytes / immunology*
-
Th1 Cells / immunology
Substances
-
Antigens, Surface
-
CD4 Antigens
-
CD8 Antigens
-
CXCR3 protein, human
-
Chemokines
-
Receptors, CXCR3
-
Receptors, Chemokine