Abstract
L-NAME (Nw-Nitro-L-arginine methylester) and L-NMMA (NG- Monomethyl-L-arginine, monoacetate) are used widely as nitric oxide (NO) synthase inhibitors. Because of their functional groups (alcohols, amines and carboxylates), it appeared that they could interact with iron in a variety of systems. Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine. This suggests that L-NAME and L-NMMA could have effects in iron containing systems found intracellularly apart from their inhibition of (NO) synthesis.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Oxidoreductases / antagonists & inhibitors*
-
Arginine / analogs & derivatives*
-
Arginine / pharmacology
-
Cytochrome c Group / metabolism
-
Epinephrine / pharmacology
-
Fatty Acids, Unsaturated / pharmacology
-
Ferrous Compounds / metabolism
-
NG-Nitroarginine Methyl Ester
-
Nitric Oxide Synthase
-
Oxidation-Reduction
-
omega-N-Methylarginine
Substances
-
Cytochrome c Group
-
Fatty Acids, Unsaturated
-
Ferrous Compounds
-
omega-N-Methylarginine
-
Arginine
-
Nitric Oxide Synthase
-
Amino Acid Oxidoreductases
-
NG-Nitroarginine Methyl Ester
-
Epinephrine