Abstract
The matrix-degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones. It is suggested that the coordinated regulation of matrix metalloproteinases and their inhibitors by these agents modify the integrity of the extracellular matrix. These modifications may, at least in part, be responsible for mediating the effects of these factors on complex physiological processes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Biological Factors / physiology
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Extracellular Matrix Proteins / metabolism*
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Gene Expression Regulation, Enzymologic
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Glycoproteins / metabolism
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Mammals / genetics
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Mammals / metabolism
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Metalloendopeptidases / antagonists & inhibitors
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Metalloendopeptidases / classification
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Metalloendopeptidases / genetics
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Metalloendopeptidases / metabolism*
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Metalloendopeptidases / physiology
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Molecular Sequence Data
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Protein Conformation
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Signal Transduction
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Tissue Inhibitor of Metalloproteinases
Substances
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Bacterial Proteins
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Biological Factors
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Extracellular Matrix Proteins
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Glycoproteins
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Tissue Inhibitor of Metalloproteinases
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Metalloendopeptidases