Abstract
In this report we describe the isolation and characterization of a cDNA clone overexpressed tenfold during the induction of apoptosis in the glucocorticoid-sensitive human leukaemia cell line CEM C7. This clone was shown by DNA sequence analysis to represent the human HL14 gene, encoding a beta-galactoside binding protein, the mouse homologue of which has recently been reported to act as a cell growth inhibitory factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Blotting, Northern
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Carrier Proteins / genetics
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Cell Cycle
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Cell Division
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Cell Line
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Cell Survival / drug effects
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Cloning, Molecular
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DNA, Neoplasm / genetics*
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DNA, Neoplasm / isolation & purification
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Dexamethasone / pharmacology*
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Galactosides / metabolism
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Galectins
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Gene Expression Regulation, Neoplastic / drug effects*
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Gene Library
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Hemagglutinins / genetics*
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Molecular Sequence Data
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Poly A / genetics
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Poly A / isolation & purification
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RNA / genetics
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RNA / isolation & purification
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RNA, Messenger / genetics
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RNA, Messenger / isolation & purification
Substances
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Carrier Proteins
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DNA, Neoplasm
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Galactosides
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Galectins
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Hemagglutinins
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RNA, Messenger
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Poly A
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RNA
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Dexamethasone
Associated data
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GENBANK/M64714
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GENBANK/M74781
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GENBANK/M74783
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GENBANK/M74784
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GENBANK/M74785
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GENBANK/M74786
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GENBANK/M74787
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GENBANK/M74788
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GENBANK/M74790
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GENBANK/S44881