Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death

Biochem Biophys Res Commun. 1991 Jul 31;178(2):746-50. doi: 10.1016/0006-291x(91)90171-3.

Abstract

In this report we describe the isolation and characterization of a cDNA clone overexpressed tenfold during the induction of apoptosis in the glucocorticoid-sensitive human leukaemia cell line CEM C7. This clone was shown by DNA sequence analysis to represent the human HL14 gene, encoding a beta-galactoside binding protein, the mouse homologue of which has recently been reported to act as a cell growth inhibitory factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / genetics
  • Cell Cycle
  • Cell Division
  • Cell Line
  • Cell Survival / drug effects
  • Cloning, Molecular
  • DNA, Neoplasm / genetics*
  • DNA, Neoplasm / isolation & purification
  • Dexamethasone / pharmacology*
  • Galactosides / metabolism
  • Galectins
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Gene Library
  • Hemagglutinins / genetics*
  • Molecular Sequence Data
  • Poly A / genetics
  • Poly A / isolation & purification
  • RNA / genetics
  • RNA / isolation & purification
  • RNA, Messenger / genetics
  • RNA, Messenger / isolation & purification

Substances

  • Carrier Proteins
  • DNA, Neoplasm
  • Galactosides
  • Galectins
  • Hemagglutinins
  • RNA, Messenger
  • Poly A
  • RNA
  • Dexamethasone

Associated data

  • GENBANK/M64714
  • GENBANK/M74781
  • GENBANK/M74783
  • GENBANK/M74784
  • GENBANK/M74785
  • GENBANK/M74786
  • GENBANK/M74787
  • GENBANK/M74788
  • GENBANK/M74790
  • GENBANK/S44881