High-pass resolution perimetry and age-related loss of visual pathway neurons

Acta Ophthalmol (Copenh). 1991 Aug;69(4):511-5. doi: 10.1111/j.1755-3768.1991.tb02030.x.

Abstract

The normal, age-related decline of results of high-pass resolution perimetry (HRP) predicts a loss of approximately 9,000 retino-cortical neural channels per year of age, or about 1 channel each hour. Previously published counts of numbers of neurons in the optic nerve indicate a loss of approximately 5,000 neurons per year. The HRP results can be accounted for by postulating that neurons are lost at the same rate also in the geniculo-striate visual pathway.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Axons
  • Cell Count
  • Child
  • Humans
  • Middle Aged
  • Optic Nerve / cytology
  • Retinal Ganglion Cells / cytology*
  • Visual Field Tests*
  • Visual Pathways*