Profound hypotony associated with loss of vision complicating bilateral chronic uveitis was managed in five consecutive patients with vitrectomy and silicone oil injection. The use of silicone oil facilitated anatomic reattachment in three of the five eyes, improved visual acuity in all five eyes, and increased or maintained the intraocular pressure (IOP) in four of the five eyes at the 6-month follow-up examination. At the time of the last follow-up examination (mean = 19 months), the IOP was still improved or maintained in four eyes and the visual acuity improved in relation to the baseline in three eyes.