Thyroid-associated ophthalmopathy--a model for the association of organ-specific autoimmune disorders

J R Wall; M Salvi; N F Bernard; A Boucher; D Haegert

doi:10.1016/S0167-5699(05)80044-1

Thyroid-associated ophthalmopathy--a model for the association of organ-specific autoimmune disorders

Immunol Today. 1991 May;12(5):150-3. doi: 10.1016/S0167-5699(05)80044-1.

Authors

J R Wall¹, M Salvi, N F Bernard, A Boucher, D Haegert

Affiliation

¹ McGill University Thyroid Center, Montreal, Quebec, Canada.

PMID: 1878126
DOI: 10.1016/S0167-5699(05)80044-1

Abstract

The development of a characteristic ophthalmopathy is a feature of autoimmune diseases of the thyroid. The link between the conditions has not yet been discovered, but here Jack Wall and colleagues develop the theory that an autoimmune response to a 64 kDa antigen expressed on both thyroid and eye muscle membranes is responsible for this thyroid-associated ophthalmopathy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Autoantigens / immunology
Autoimmune Diseases / immunology*
Cross Reactions / immunology
Graves Disease / immunology*
Humans
Models, Biological
Oculomotor Muscles / immunology
Orbit / immunology
Thyroid Gland / immunology
Thyroiditis, Autoimmune / immunology*

Substances

Autoantigens