Quantitative autoradiography of beta-adrenergic receptors in rabbit eyes

Exp Eye Res. 1990 Nov;51(5):503-7. doi: 10.1016/0014-4835(90)90080-e.

Abstract

Beta-adrenergic receptors were localized and quantified with autoradiographic methods in frozen sections of eyes of albino rabbits using [125I]cyanopindolol and [3H]dihydroalprenolol. Quantification in albino rabbits revealed highest beta 2-adrenoceptor densities in the ciliary body, the corneal epithelium and the corneal endothelium. Moreover, the iris showed significant amounts of specific binding, whereas the retina and sclera are nearly free of these receptors.

MeSH terms

  • Adrenergic beta-Antagonists / metabolism
  • Animals
  • Autoradiography
  • Ciliary Body / chemistry
  • Cornea / chemistry
  • Endothelium, Corneal / chemistry
  • Epithelium / chemistry
  • Eye / chemistry*
  • Eye / metabolism
  • Female
  • Frozen Sections
  • Iris / chemistry
  • Male
  • Pindolol / analogs & derivatives
  • Pindolol / metabolism
  • Rabbits
  • Receptors, Adrenergic, beta / analysis*

Substances

  • Adrenergic beta-Antagonists
  • Receptors, Adrenergic, beta
  • cyanopindolol
  • Pindolol