A young woman developed acute macular neuroretinopathy in one eye and five years later developed the multiple evanescent white dot syndrome in the same eye. Another young woman developed unilateral multiple evanescent white dot syndrome and central macular lesions typical of acute macular neuroretinopathy that appeared soon after the peripheral macular and juxtapapillary white lesions resolved. The findings in these two patients suggest that these two relatively rare syndromes may have pathogenetic and etiologic features in common.