A characteristic retinal phototoxicity reaction was noted in four patients who underwent penetrating keratoplasty, extracapsular cataract extraction (ECCE), and intraocular lens (IOL) implantation. This complication has been well documented in association with other ocular procedures, but only one previous similar case has been reported. The authors bring this potential complication to the attention of corneal surgeons, discuss the risk factors, and offer suggestions on prevention.