Although there have been no radical breakthroughs in the treatment of fungal keratitis from the point of view of new antifungal agents, a better understanding of the epidemiology and pathology of the disease, as well as the drugs available and the appropriate surgical interventions, has led to an improvement in the management of this difficult corneal infection. In this paper the therapy of fungal keratitis will be reviewed in detail in the light of the known causative organisms and the pharmacology and pharmacokinetics of available antifungal agents.