Management of posterior capsule rupture and vitreous loss associated with intraocular lens implantation is described and the results of the procedure statistically analyzed. Vitreous loss occurred in 18 (4.3%) of the 416 eyes treated during a one-year period. Of these 18 eyes, 11 received posterior chamber lenses and seven received anterior chamber lenses; all lenses remained adequately fixated. The visual acuity, incidence of postoperative complications, and endothelial cell loss were not significantly different in the eyes that had posterior capsule rupture and vitreous loss and in the control eyes. Although posterior chamber lens implantation is not necessarily contraindicated in eyes with vitreous loss, instances of high endothelial cell loss suggest the need for greater attention to the endothelial cells during vitrectomy.