Abstract
Autotransplantation of 250,000 tissue cultured fibroblasts from rabbit rump skin into the vitreous cavity results in intravitreal strand formation and traction retinal detachment (27 of 47 eyes, 57%). A single intravitreal injection of 1 mg of dexamethasone alcohol inhibits fibroblast growth as judged by the significantly reduced number of retinal detachments (11 of 46 eyes, 24%).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cells, Cultured
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Dexamethasone / pharmacology
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Dexamethasone / therapeutic use*
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Eye Diseases / prevention & control
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Fibroblasts / drug effects
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Fibroblasts / transplantation
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Rabbits
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Retinal Detachment / etiology
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Retinal Detachment / prevention & control*
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Transplantation, Autologous
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Vitreous Body / drug effects*