We evaluated foveal cone photopigment kinetics by retinal densitometry in 14 patients (12 men and two women, ranging in age from 30 to 54 years) with central serous choroidopathy. At the initial examinations when 12 of the 14 patients showed active leaks, the measured two-way density of pigment was low and the time-course of regeneration was slow. At later examinations, we found low two-way densities with normal regeneration times in five patients without active leakage. Near normal two-way densities occurred only in three patients who had complete clinical recoveries.