Abstract
7-Nitroindazole induced concentration-dependent relaxation of precontracted rabbit aorta, dog middle cerebral artery, rat anococcygeus muscle and rat stomach fundus. Relaxations to 7-nitroindazole in rabbit aorta were unaffected by nitric oxide synthase blockade or endothelial removal. 6-Nitroindazole also caused concentration-dependent relaxation in dog middle cerebral artery and rabbit aorta, being equipotent with 7-nitroindazole in both tissues. These data suggest that indazole derivatives can induce an endothelium- and nitric oxide synthase-independent relaxation of smooth muscle in vitro.
MeSH terms
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Alprazolam / pharmacology
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Animals
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Azepines / pharmacology
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Colitis / chemically induced
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Colitis / physiopathology
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Colon / drug effects
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Colon / metabolism*
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Gastrointestinal Motility / drug effects*
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In Vitro Techniques
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Iodine Radioisotopes
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Neuropeptides / metabolism*
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Neuropeptides / physiology
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Platelet Activating Factor / antagonists & inhibitors
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Platelet Activating Factor / pharmacology*
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Rabbits
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Substance P / metabolism
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Substance P / physiology
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Triazoles / pharmacology
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Vasoactive Intestinal Peptide / metabolism
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Vasoactive Intestinal Peptide / physiology
Substances
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Azepines
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Iodine Radioisotopes
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Neuropeptides
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Platelet Activating Factor
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Triazoles
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Substance P
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Vasoactive Intestinal Peptide
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bepafant
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Alprazolam