Macular holes. Pathogenesis, natural history and surgical outcomes

Aust N Z J Ophthalmol. 1995 May;23(2):93-100. doi: 10.1111/j.1442-9071.1995.tb00136.x.

Abstract

Idiopathic full-thickness macular holes (FTMH) are a common cause of usually uniocular reduced visual acuity. The accepted pathogenesis has macular hole formation proceeding in stages from an impending hole to a FTMH, with visual acuity deteriorating to less than 6/60 in 85% of cases. Recent surgical advances in the treatment of FTMH, with excellent anatomic and visual results, have changed the surgical indications for both impending and established full-thickness macular holes.

Publication types

  • Review

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Female
  • Fluorescein Angiography
  • Fluorocarbons / administration & dosage
  • Fundus Oculi
  • Growth Substances / blood
  • Humans
  • Male
  • Retina / pathology
  • Retina / surgery
  • Retinal Perforations / diagnosis
  • Retinal Perforations / etiology*
  • Retinal Perforations / surgery*
  • Transforming Growth Factor beta / administration & dosage
  • Treatment Outcome
  • Visual Acuity
  • Vitrectomy

Substances

  • Fluorocarbons
  • Growth Substances
  • Transforming Growth Factor beta
  • perflutren