Abstract
Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA / administration & dosage
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DNA / genetics
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Female
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Genes, Lethal
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Genetic Vectors
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Humans
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Male
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Mice
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Mice, Transgenic / genetics*
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Microinjections
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Mutagenesis, Insertional / methods*
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Mutation
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Pregnancy
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Retroviridae / genetics