Abstract
Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Aspergillus fumigatus / pathogenicity
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Bacteriological Techniques
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Cornea / microbiology*
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Cornea / pathology
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Culture Techniques
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Disease Models, Animal*
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Fusarium*
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Haplorhini
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Keratitis* / drug therapy
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Keratitis* / microbiology
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Keratitis* / pathology
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Mycoses* / drug therapy
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Mycoses* / microbiology
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Mycoses* / pathology
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Ointments
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Prednisolone / administration & dosage
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Prednisolone / therapeutic use
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Rabbits*
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Triamcinolone / administration & dosage
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Triamcinolone / therapeutic use
Substances
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Anti-Bacterial Agents
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Ointments
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Triamcinolone
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Prednisolone