Purpose: We studied a case of squamous cell carcinoma of the eyelid in a 42-year-old homosexual man with the acquired immunodeficiency syndrome (AIDS) to explore the link between squamous cell carcinoma and human Papillomavirus infection.
Method: A rapidly growing, 3-mm lesion was removed from the right lower eyelid by excisional biopsy.
Results: Examination of the lesion confirmed squamous cell carcinoma. Polymerase chain reaction for human Papillomavirus 16 was positive.
Conclusion: This case suggests a role for human Papillomavirus infection in the cause of squamous cell carcinoma in AIDS patients.