Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye

Ophthalmologica. 1996;210(2):119-22. doi: 10.1159/000310687.

Abstract

The authors evaluated the ocular absorption of ciprofloxacin, ofloxacin and gentamicin as a reference drug in a novel model of ocular inflammation. The ocular absorption of ciprofloxacin and ofloxacin was shown to be increased two- to threefold in the inflamed eye. The absorption of gentamicin was undetectable in the normal eye and very poor in the inflamed eye.

Publication types

  • Comparative Study

MeSH terms

  • Absorption
  • Administration, Topical
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / pharmacokinetics*
  • Aqueous Humor / metabolism
  • Blood-Aqueous Barrier
  • Chromatography, High Pressure Liquid
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / pharmacokinetics*
  • Cornea / metabolism
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Gentamicins / administration & dosage
  • Gentamicins / pharmacokinetics*
  • Infusions, Intravenous
  • Keratitis / drug therapy
  • Keratitis / metabolism*
  • Male
  • Ofloxacin / administration & dosage
  • Ofloxacin / pharmacokinetics*
  • Ophthalmic Solutions
  • Rabbits

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Gentamicins
  • Ophthalmic Solutions
  • Ciprofloxacin
  • Ofloxacin