Abstract
The authors evaluated the ocular absorption of ciprofloxacin, ofloxacin and gentamicin as a reference drug in a novel model of ocular inflammation. The ocular absorption of ciprofloxacin and ofloxacin was shown to be increased two- to threefold in the inflamed eye. The absorption of gentamicin was undetectable in the normal eye and very poor in the inflamed eye.
MeSH terms
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Absorption
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Administration, Topical
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacokinetics*
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / pharmacokinetics*
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Aqueous Humor / metabolism
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Blood-Aqueous Barrier
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Chromatography, High Pressure Liquid
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / pharmacokinetics*
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Cornea / metabolism
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Gentamicins / administration & dosage
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Gentamicins / pharmacokinetics*
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Infusions, Intravenous
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Keratitis / drug therapy
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Keratitis / metabolism*
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Male
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Ofloxacin / administration & dosage
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Ofloxacin / pharmacokinetics*
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Ophthalmic Solutions
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Rabbits
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Gentamicins
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Ophthalmic Solutions
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Ciprofloxacin
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Ofloxacin