Abstract
The effects of four days' treatment with topical Maxitrol (neomycin sulphate 3500 IU/mL, polymyxin-B sulphate 6000 IU/mL with dexamethasone 0.1%) were compared with those of Maxidex (dexamethasone 0.1% alone) in a double-masked study in 111 patients with bacterial blepharitis or conjunctivitis, 95 of whom were evaluable for efficacy. The majority of patients (N = 80) had chronic blepharitis. Maxitrol treatment resulted in a significantly greater reduction (90%) in bacterial counts and bacterial eradication (50%) compared with Maxidex (34% and 17% respectively). Maxitrol treatment also produced a significantly greater reduction in conjunctival discharge than did Maxidex, while the treatments were equally effective in alleviating other ocular signs and symptoms. It was concluded that use of a fixed dose combination steroid-antibiotic product was more effective for bacterial control and therapeutic efficacy in the treatment of chronic blepharitis and conjunctivitis patients than treatment with steroid alone. However, in the long-term treatment of chronic blepharitis the well-known toxic problems of neomycin sulphate have to be taken into account.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use*
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Blepharitis / drug therapy*
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Blepharitis / microbiology
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Chronic Disease
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Colony Count, Microbial
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Conjunctiva / drug effects
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Conjunctiva / microbiology
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Conjunctivitis, Bacterial / drug therapy*
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Conjunctivitis, Bacterial / etiology
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Dexamethasone / administration & dosage
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Dexamethasone / adverse effects
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Dexamethasone / therapeutic use*
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Double-Blind Method
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Drug Combinations
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Eye Infections, Bacterial / drug therapy
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Eye Infections, Bacterial / etiology
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Eyelids / drug effects
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Eyelids / microbiology
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Female
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Fluprednisolone / administration & dosage
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Fluprednisolone / adverse effects
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Fluprednisolone / therapeutic use*
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Glucocorticoids
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Gram-Negative Bacteria / isolation & purification
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Gram-Positive Bacteria / isolation & purification
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Humans
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Male
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Middle Aged
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Neomycin / administration & dosage
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Neomycin / adverse effects
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Neomycin / therapeutic use*
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Ophthalmic Solutions
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Polymyxin B / administration & dosage
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Polymyxin B / adverse effects
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Polymyxin B / therapeutic use*
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Drug Combinations
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Glucocorticoids
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Ophthalmic Solutions
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Maxitrol
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Dexamethasone
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Fluprednisolone
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Neomycin
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Polymyxin B