An estimated 30 million people worldwide have been infected with the human immunodeficiency virus, the causative agent of the acquired immunodeficiency syndrome. Of these, 90% live in developing countries from where there is relatively little published information about the ocular manifestations of human immunodeficiency virus and acquired immunodeficiency syndrome. We review the information available from Africa, Latin America, and Asia. The prevailing ocular manifestations differ in some developing countries compared with those in the industrialized countries. These differences most likely result from different socioeconomic conditions and basic health care availability and from different patterns of endemic disease present before the human immunodeficiency virus epidemic.