Abstract
Systemic injection of antigen is one of the approaches that reproducibly induces effective antigen-specific hyporesponsiveness. Here, Roland Liblau and colleagues discuss the cellular and molecular bases of such tolerance, review the current use of this therapeutic strategy in experimental organ-specific autoimmune diseases and analyse what steps are necessary to make this approach suitable for clinical use.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens / therapeutic use*
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / therapy*
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Diabetes Mellitus, Type 1 / therapy
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Encephalomyelitis, Autoimmune, Experimental / therapy
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Humans
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Immune Tolerance
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Immunotherapy
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Lymphocyte Depletion
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Mice
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Mice, Inbred NOD
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Mice, Transgenic
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T-Lymphocytes / immunology*