Abstract
Objective:
To describe ocular findings in 2 patients with disseminated coccidioidomycosis diagnosed by skin biopsy.
Methods:
The clinical and histopathologic findings of the 2 patients were reviewed retrospectively.
Results:
One patient had a unilateral, granulomatous iridocyclitis with multiple iris nodules and a large vascularized anterior chamber mass, in the setting of pulmonary, cutaneous, and skeletal infection by Coccidioides immitis. The second patient developed papilledema and multifocal chorioretinitis accompanied by pulmonary, cutaneous, and meningeal C immitis infection. In each case, examination of the skin biopsy specimen revealed C immitis spherules. Treatments included local and systemic amphotericin B and oral fluconazole.
Conclusions:
Although rare, intraocular involvement can occur in the setting of disseminated coccidioidomycosis. A thorough systemic evaluation and biopsy of suspicious skin lesions can aid in the diagnosis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amphotericin B / therapeutic use
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Biopsy
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Bone Diseases / diagnostic imaging
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Bone Diseases / drug therapy
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Bone Diseases / microbiology
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Brain Diseases / diagnostic imaging
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Brain Diseases / drug therapy
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Brain Diseases / microbiology
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Chorioretinitis / diagnosis*
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Chorioretinitis / drug therapy
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Chorioretinitis / microbiology
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Coccidioidomycosis / diagnosis*
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Coccidioidomycosis / drug therapy
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Coccidioidomycosis / microbiology
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Dermatomycoses / diagnosis*
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Dermatomycoses / drug therapy
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Dermatomycoses / microbiology
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Eye Infections, Fungal / diagnosis*
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Eye Infections, Fungal / drug therapy
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Eye Infections, Fungal / microbiology
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Female
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Fluconazole / therapeutic use
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Humans
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Iridocyclitis / diagnosis*
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Iridocyclitis / drug therapy
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Iridocyclitis / microbiology
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Lung Diseases, Fungal / diagnostic imaging
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Lung Diseases, Fungal / drug therapy
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Male
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Radiography
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Radionuclide Imaging
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Retrospective Studies
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Skin / microbiology
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Skin / pathology*
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Technetium Tc 99m Pyrophosphate
Substances
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Technetium Tc 99m Pyrophosphate
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Amphotericin B
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Fluconazole