Although many biologists have embraced microbial model systems as tools to address
genetic and physiological questions, the explicit use of microbial communities as model …

Neuropoietic cytokines are well known for their role in the control of neuronal, glial and
immune responses to injury or disease. Since this discovery, it has emerged that several of …

The primary sensory neurons that respond to noxious stimulation and project to the spinal
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …

One of the central aims of ecology is to identify mechanisms that maintain biodiversity,.
Numerous theoretical models have shown that competing species can coexist if ecological …

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium
channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant …

Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …

A number of drugs inhibit the metabolism of carbamazepine catalyzed by cytochrome P450,
sometimes resulting in carbamazepine intoxication. However, there is little information …

Familial hypertrophic cardiomyopathy (HCM) has been widely studied as a genetic model of
cardiac hypertrophy and sudden cardiac death. HCM has been defined as a disease of the …

Neurofibromatosis type 1 (NF1) is characterized by café-au-lait spots, skinfold freckling, and
cutaneous neurofibromas. No obvious relationships between small mutations (< 20 bp) of …

Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized
by the co-occurrence of epilepsy and intellectual disability (ID), typically with developmental …