Transplantation of ex vivo cultured limbal epithelial stem cells: a review of techniques and clinical results
Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …
Matrix metalloproteinases in disease and repair processes in the anterior segment
TTL Wong, C Sethi, JT Daniels, GA Limb… - Survey of …, 2002 - Elsevier
The pathogenesis of many anterior segment disorders and ocular complications following
surgery are secondary to the wound healing response. The extent of clinical damage …
surgery are secondary to the wound healing response. The extent of clinical damage …
Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies
Neural cell death is the main feature of all retinal degenerative disorders that lead to
blindness. Despite therapeutic advances, progression of retinal disease cannot always be …
blindness. Despite therapeutic advances, progression of retinal disease cannot always be …
MIO-M1 cells and similar Müller glial cell lines derived from adult human retina exhibit neural stem cell characteristics
JM Lawrence, S Singhal, B Bhatia, DJ Keegan… - Stem …, 2007 - academic.oup.com
Growing evidence suggests that glial cells may have a role as neural precursors in the adult
central nervous system. Although it has been shown that Müller cells exhibit progenitor …
central nervous system. Although it has been shown that Müller cells exhibit progenitor …
[HTML][HTML] In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1)
purpose. To characterize a spontaneously immortalized human Müller cell line and to
determine whether it retains the characteristics of primary isolated cells without undergoing …
determine whether it retains the characteristics of primary isolated cells without undergoing …
Cytokines in proliferative vitreoretinopathy
GA Limb, BC Little, A Meager, JA Ogilvie… - Eye, 1991 - nature.com
This study determined the presence of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour
necrosis factor α (TNFa), tumour necrosis factor β (TNFβ), interferon γ (IFNγ), transforming …
necrosis factor α (TNFa), tumour necrosis factor β (TNFβ), interferon γ (IFNγ), transforming …
[HTML][HTML] Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE)
H Zong, M Ward, A Madden, PH Yong, GA Limb… - Diabetologia, 2010 - Springer
Aims/hypothesis Up-regulation of the receptor for AGEs (RAGE) and its ligands in diabetes
has been observed in various tissues. Here, we sought to determine levels of RAGE and …
has been observed in various tissues. Here, we sought to determine levels of RAGE and …
Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy.
GA Limb, AH Chignell, W Green, F LeRoy… - British Journal of …, 1996 - bjo.bmj.com
AIMS: This study investigated the presence of the cytokine tumour necrosis factor alpha
(TNF alpha) and the vascular adhesion glycoproteins ICAM-1, VCAM-1, E-selectin, P …
(TNF alpha) and the vascular adhesion glycoproteins ICAM-1, VCAM-1, E-selectin, P …
Cytokines in human intraocular inflammation
WA Franks, GA Limb, MR Stanford, J Ogilvie… - Current eye …, 1992 - Taylor & Francis
The presence of interleukin 6 (IL-6), interleukin 1 (IL-1), interleukin 2 (IL-2) and tumour
necrosis factor (TNF) was investigated in vitreous and aqueous aspirates from eyes …
necrosis factor (TNF) was investigated in vitreous and aqueous aspirates from eyes …
Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following …
S Singhal, B Bhatia, H Jayaram… - Stem cells …, 2012 - academic.oup.com
Müller glia with stem cell characteristics have been identified in the adult human eye, and
although there is no evidence that they regenerate retina in vivo, they can be induced to …
although there is no evidence that they regenerate retina in vivo, they can be induced to …