User profiles for "author:Gangxiang Yuan"

Gangxiang Yuan

State Key Laboratory of Silkworm Genome Biology
Verified email at email.swu.edu.cn
Cited by 489

[PDF][PDF] Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling

J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan… - Cell reports, 2021 - cell.com
Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy
balance and host metabolism via G protein-coupled receptors and/or nuclear receptors …

[HTML][HTML] Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling

J Hu, Y Zhang, S Yi, C Wang, X Huang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Dendritic cells (DCs) are the major antigen-presenting cells and play an important role in
autoimmune uveitis. Emerging evidence suggests that bile acids (BAs) regulate DCs …

Identification of novel risk loci for Behçet's disease–related uveitis in a Chinese population in a genome‐wide association study

G Su, Z Zhong, Q Zhou, L Du, Z Ye, F Li… - Arthritis & …, 2022 - Wiley Online Library
Objective To explore susceptibility loci associated with uveitis in Behçet's disease (BD).
Methods We conducted a 2‐stage study, consisting of a genome‐wide association study …

MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease

R Chang, S Yi, X Tan, Y Huang, Q Wang… - British Journal of …, 2018 - bjo.bmj.com
Aim To elucidate the role of microRNA-20a-5p (miR-20a-5p) in the pathogenesis of Vogt-
Koyanagi-Harada (VKH) disease. Methods Quantitative real-time PCR was used to quantify …

[HTML][HTML] Changes in the Gut Microbiome Contribute to the Development of Behcet's Disease via Adjuvant Effects

Q Wang, S Yi, G Su, Z Du, S Pan, X Huang… - Frontiers in Cell and …, 2021 - frontiersin.org
Behcet's disease (BD) is associated with considerable gut microbiome changes. However, it
still remains unknown how the composition of the gut microbiome exactly affects the …

[HTML][HTML] Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population

M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang… - Scientific Reports, 2016 - nature.com
Cell adhesion molecules (CAMs) are involved in various immune-mediated diseases. This
study was conducted to investigate the association of single nucleotide polymorphisms …

Epigenome-wide association study identifies Behcet's disease-associated methylation loci in Han Chinese

H Yu, L Du, S Yi, Q Wang, Y Zhu, Y Qiu, Y Jiang… - …, 2019 - academic.oup.com
Abstract Objective The aetiology of Behçet's disease (BD), known as a systemic vasculitis, is
not completely understood. Increasing evidence suggests that aberrant DNA methylation …

Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis

Z Du, Q Wang, X Huang, S Yi, S Mei, G Yuan… - International …, 2020 - Elsevier
Background Berberine (BBR) was reported to have immunoregulatory and anti-inflammatory
properties. In this study, we investigated whether BBR could exert its effects on the …

Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet's disease in a Chinese Han population

P Wu, L Du, S Hou, G Su, L Yang, J Hu… - British Journal of …, 2018 - bjo.bmj.com
Background An Immunochip study recently identified the association of a number of new
genetic loci with Behcet's disease (BD). Objective To confirm the association between new …

[HTML][HTML] Association of genetic variations in TNFSF15 with acute anterior uveitis in Chinese Han

H Li, S Hou, H Yu, M Zheng, L Zhang… - … & Visual Science, 2015 - arvojournals.org
Purpose: T cells play an important role in the pathogenesis of uveitis. Recent studies have
indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the …