Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography

KA Vermeer, J Mo, JJA Weda, HG Lemij… - Biomedical optics …, 2014 - opg.optica.org
We present a method, based on a single scattering model, to calculate the attenuation
coefficient of each pixel in optical coherence tomography (OCT) depth profiles. Numerical …

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

PG Hysi, CY Cheng, H Springelkamp, S Macgregor… - Nature …, 2014 - nature.com
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and
variability in IOP might herald glaucomatous development or progression. We report the …

[HTML][HTML] A genome-wide association study of optic disc parameters

WD Ramdas, LME van Koolwijk, MK Ikram… - PLoS …, 2010 - journals.plos.org
The optic nerve head is involved in many ophthalmic disorders, including common diseases
such as myopia and open-angle glaucoma. Two of the most important parameters are the …

[HTML][HTML] Common genetic determinants of intraocular pressure and primary open-angle glaucoma

LME van Koolwijk, WD Ramdas, MK Ikram… - PLoS …, 2012 - journals.plos.org
Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma
and is the only target for current glaucoma therapy. The genetic factors which determine IOP …

A model based method for retinal blood vessel detection

KA Vermeer, FM Vos, HG Lemij… - Computers in biology and …, 2004 - Elsevier
Retinal blood vessels are important structures in ophthalmological images. Many detection
methods are available, but the results are not always satisfactory. In this paper, we present a …

Common genetic variants associated with open-angle glaucoma

WD Ramdas, LME van Koolwijk… - Human molecular …, 2011 - academic.oup.com
Open-angle glaucoma (glaucoma) is a major eye disorder characterized by optic disc
pathology. Recent genome-wide association studies identified new loci associated with …

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics

H Springelkamp, AI Iglesias, A Mishra… - Human molecular …, 2017 - academic.oup.com
Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable
disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease …

Meta‐analysis of genome‐wide association studies identifies novel loci associated with optic disc morphology

H Springelkamp, A Mishra, PG Hysi… - Genetic …, 2015 - Wiley Online Library
Primary open‐angle glaucoma is the most common optic neuropathy and an important
cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in …

Automated segmentation by pixel classification of retinal layers in ophthalmic OCT images

KA Vermeer, J Van der Schoot, HG Lemij… - Biomedical optics …, 2011 - opg.optica.org
Current OCT devices provide three-dimensional (3D) in-vivo images of the human retina.
The resulting very large data sets are difficult to manually assess. Automated segmentation …

Clinical assessment of stereoscopic optic disc photographs for glaucoma: the European Optic Disc Assessment Trial

NJ Reus, HG Lemij, DF Garway-Heath, PJ Airaksinen… - Ophthalmology, 2010 - Elsevier
PURPOSE: To determine the diagnostic accuracy of judging optic disc photographs for
glaucoma by ophthalmologists. DESIGN: Evaluation of diagnostic test and technology …