Objective To develop a new evidence‐based, pharmacologic treatment guideline for
rheumatoid arthritis (RA). Methods We conducted systematic reviews to synthesize the …

The American College of Rheumatology (ACR) most recently published recommendations
for the use of diseasemodifying antirheumatic drugs (DMARDs) and biologic agents in the …

As far back as the industrial revolution, significant development in technical innovation has
succeeded in transforming numerous manual tasks and processes that had been in …

Background In 2010, overweight and obesity were estimated to cause 3· 4 million deaths, 3·
9% of years of life lost, and 3· 8% of disability-adjusted life-years (DALYs) worldwide. The …

Background Among breast cancers without human epidermal growth factor receptor 2
(HER2) amplification, overexpression, or both, a large proportion express low levels of …

Importance Understanding the major health problems in the United States and how they are
changing over time is critical for informing national health policy. Objectives To measure the …

An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in
Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 …

Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer …

Objective To develop updated guidelines for the pharmacologic management of rheumatoid
arthritis. Methods We developed clinically relevant population, intervention, comparator, and …

Context Existing therapies for major depression have a lag of onset of action of several
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …