Mitochondria are involved in many biological processes including cellular homeostasis,
energy generation, and apoptosis. Moreover, mitochondrial and metabolic pathways are …

Abstract Venetoclax, a Bcl-2 inhibitor, in combination with the hypomethylating agent
azacytidine, achieves complete remission with or without count recovery in∼ 70% of …

With recent clinical breakthroughs, immunotherapy has become the fourth pillar of cancer
treatment. Particularly, immune cell-based therapies have been envisioned as a promising …

The development of autologous chimeric antigen receptor T (CAR-T) cell therapies has
revolutionized cancer treatment. Nevertheless, the delivery of CAR-T cell therapy faces …

Significant improvements in the survival of patients with hematological cancers following
hematopoietic stem cell transplantation provide evidence supporting the potency of immune …

Background While conventional chemotherapy is effective at eliminating the bulk of
leukemic cells, chemotherapy resistance in acute myeloid leukemia (AML) is a prevalent …

Background Though immune checkpoint blockade (ICB) against PD-1 has shown success in
the treatment of lung cancer, not all patients respond. We have previously shown that …

Background The advents of novel immunotherapies have revolutionized the treatment of
cancer. Adoptive cellular therapies using chimeric antigen receptor T (CAR-T) cells have …

Acute myeloid leukemia (AML) remains a devastating disease in need of new therapies to
improve patient survival. Targeted adoptive T-cell therapies have achieved impressive …

Purpose: To expand clinical-grade healthy donor-derived double-negative T cells (DNT) to a
therapeutically relevant number and characterize their potential to be used as an “off-the …