Neuropathic pain and dry eye
Dry eye is a common, multifactorial disease currently diagnosed by a combination of
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …
Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders
Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to
correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma …
correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma …
[HTML][HTML] Neuropathic ocular pain due to dry eye is associated with multiple comorbid chronic pain syndromes
Recent data show that dry eye (DE) susceptibility and other chronic pain syndromes (CPS)
such as chronic widespread pain, irritable bowel syndrome, and pelvic pain, might share …
such as chronic widespread pain, irritable bowel syndrome, and pelvic pain, might share …
Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain
Objective Studies of patients with non-ocular pain suggest that it is therapeutically useful to
identify those with features of neuropathic pain. No data is available, however, on whether …
identify those with features of neuropathic pain. No data is available, however, on whether …
[HTML][HTML] ω-3 tear film lipids correlate with clinical measures of dry eye
SD Walter, K Gronert, AL McClellan… - … & visual science, 2016 - iovs.arvojournals.org
Purpose: ω-3 and ω-6 polyunsaturated fatty acids modulate inflammatory processes
throughout the body through distinct classes of lipid mediators that possess both …
throughout the body through distinct classes of lipid mediators that possess both …
Neuropathic ocular surface pain: emerging drug targets and therapeutic implications
Introduction Dysfunction at various levels of the somatosensory system can lead to ocular
surface pain with a neuropathic component. Compared to nociceptive pain (due to noxious …
surface pain with a neuropathic component. Compared to nociceptive pain (due to noxious …
Incomplete response to artificial tears is associated with features of neuropathic ocular pain
Aims Artificial tears are first-line therapy for patients with dry eye symptoms. It is not known,
however, which patient factors associate with a positive response to therapy. The purpose of …
however, which patient factors associate with a positive response to therapy. The purpose of …
Patients with more severe symptoms of neuropathic ocular pain report more frequent and severe chronic overlapping pain conditions and psychiatric disease
Objective To study chronic pain and mental health profiles in patients with dry eye (DE)
symptoms, comparing those with high and low levels of neuropathic ocular pain (NOP) …
symptoms, comparing those with high and low levels of neuropathic ocular pain (NOP) …
Dry eye profiles in patients with a positive elevated surface matrix metalloproteinase 9 point-of-care test versus negative patients
NL Lanza, AL McClellan, H Batawi, ER Felix… - The ocular …, 2016 - Elsevier
Purpose To compare dry eye (DE) symptoms and signs in subjects who tested positive
versus those who tested negative for ocular surface matrix metalloproteinase 9 (MMP-9) …
versus those who tested negative for ocular surface matrix metalloproteinase 9 (MMP-9) …
Evidence of central sensitisation in those with dry eye symptoms and neuropathic-like ocular pain complaints: incomplete response to topical anaesthesia and …
Objective To evaluate how closely neuropathic-like ocular pain (NOP) symptoms align with a
metric of central sensitisation (ie, the presence of persistent ocular pain after topical …
metric of central sensitisation (ie, the presence of persistent ocular pain after topical …