Age-related macular degeneration

M Fleckenstein, TDL Keenan, RH Guymer… - Nature reviews Disease …, 2021 - nature.com
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

Dietary ω-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis

EWT Chong, AJ Kreis, TY Wong… - Archives of …, 2008 - jamanetwork.com
Objective To systematically review the evidence on dietary ω-3 fatty acid and fish intake in
the primary prevention of age-related macular degeneration (AMD). Methods Seven …

Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis

EWT Chong, TY Wong, AJ Kreis, JA Simpson… - Bmj, 2007 - bmj.com
Objective To evaluate the effectiveness of dietary antioxidants in the primary prevention of
age related macular degeneration (AMD). Design Systematic review and meta-analysis …

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

LG Fritsche, W Igl, JNC Bailey, F Grassmann… - Nature …, 2016 - nature.com
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …

A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy

EM Stone, AJ Lotery, FL Munier, E Héon, B Piguet… - Nature …, 1999 - nature.com
Abstract Malattia Leventinese (ML) and Doyne honeycomb retinal dystrophy (DHRD) refer to
two autosomal dominant diseases characterized by yellow-white deposits known as drusen …

Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study

FG Holz, W Amoaku, J Donate, RH Guymer, U Kellner… - Ophthalmology, 2011 - Elsevier
Objective To evaluate the safety and efficacy of individualized ranibizumab treatment in
patients with neovascular age-related macular degeneration. Design Twelve-month, phase …

Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search

L Fang, D Cunefare, C Wang, RH Guymer… - Biomedical optics …, 2017 - opg.optica.org
We present a novel framework combining convolutional neural networks (CNN) and graph
search methods (termed as CNN-GS) for the automatic segmentation of nine layer …

Tolerating subretinal fluid in neovascular age-related macular degeneration treated with ranibizumab using a treat-and-extend regimen: FLUID study 24-month results

RH Guymer, CM Markey, IL McAllister, MC Gillies… - Ophthalmology, 2019 - Elsevier
Purpose To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with
neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a …

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

Y Yu, TR Bhangale, J Fagerness, S Ripke… - Human molecular …, 2011 - academic.oup.com
Despite significant progress in the identification of genetic loci for age-related macular
degeneration (AMD), not all of the heritability has been explained. To identify variants which …

[HTML][HTML] First-in-human trial of a novel suprachoroidal retinal prosthesis

LN Ayton, PJ Blamey, RH Guymer, CD Luu… - PloS one, 2014 - journals.plos.org
Retinal visual prostheses (“bionic eyes”) have the potential to restore vision to blind or
profoundly vision-impaired patients. The medical bionic technology used to design …